Joe Mixon vs Trey Benson: Who Should You Start?
There is a real production gap between these two running backs. Joe Mixon (Houston Texans) averaged 16.5 PPG over 15 games in 2025, outscoring Trey Benson (Arizona Cardinals, 7.2 PPG) by 9.3 points per week. That separation would need a significant matchup swing to overcome.
Joe Mixon carries a 9.3-point PPG advantage from the 2025 season. That baseline matters, but it is one input among several. Matchup difficulty, scoring trends, and injury reports move the needle week to week, which is why the best answer changes depending on when you are asking.
Both profile as early-down workhorses. Joe Mixon ran for 1165 yards and 11 touchdowns; Trey Benson posted 160 and undefined. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Joe Mixon is off Week 14 and Trey Benson Week 8. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
