Joe Mixon vs Jonathan Taylor: Who Should You Start?
Deciding between Joe Mixon and Jonathan Taylor is a common lineup dilemma for fantasy managers. The Houston Texans running back put up 16.5 PPG in 2025 over 15 games; Jonathan Taylor of the Indianapolis Colts averaged 20.0 in 17. A 3.5-point margin that could shift on any given week.
The per-game difference of 3.5 points favors Jonathan Taylor, though savvy managers know that gap can shrink or widen depending on the weekly slate. Defensive matchup, recent scoring trends, and health status all shift the calculus from one running back to the other.
Jonathan Taylor is the receiving back in this matchup, turning 46 targets into 378 yards, while Joe Mixon profiles as a more traditional rusher with 1165 rushing yards and 11 touchdowns. In PPR and half-PPR formats Jonathan Taylor carries the higher weekly floor. In standard leagues the gap tightens considerably.
One scheduling note: Joe Mixon is off Week 14 and Jonathan Taylor Week 11. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
