Head to Head

Updated May 14, 2026 from live stats

James Cook vs TreVeyon Henderson

Fantasy Football Comparison for the 2026 NFL Season

The Bottom Line

James Cook is the better fantasy play this season.

James Cook is clearly the better fantasy option heading into 2026. With 16.8 PPG and 1,912 total yards in 2025, the production separation is too wide to overcome on matchup alone. TreVeyon Henderson (11.1 PPG) is a hold, not a sell, but roster James Cook as the starter and TreVeyon Henderson as depth.

High confidence: stats strongly favor the leader, and the gap is unlikely to close on matchup alone.

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RBBuffalo Bills#6PPG LEADER

James Cook

PPG

16.8

Games

Rush Yds

1,621

Rush TDs

Rec

Rec Yds

291

Bye

Week 7

RBNew England Patriots#24

TreVeyon Henderson

PPG

11.1

Games

Rush Yds

911

Rush TDs

Rec

Rec Yds

221

Bye

Week 14

The Edge Chart

James Cook

TreVeyon Henderson

Head to Head

16.8 PPG11.1 PPG

17 GP17 GP

Bye: Week 7Bye: Week 14

Fantasy Tiers

James Cook: Tier 2 (Strong Starter) RB (ranked #6 at the position). TreVeyon Henderson: Tier 3 (Flex/Starter) RB (ranked #24 at the position). Among the top 50 running backs this season, James Cook is producing at 76% of elite pace and TreVeyon Henderson at 50%. That ranking gap means James Cook carries more trade value and a higher draft cost in 2026.

James Cook vs TreVeyon Henderson: Who Should You Start?

James Cook and TreVeyon Henderson are both viable fantasy running backs heading into 2026, but their 2025 production tells two different stories. James Cook averaged 16.8 PPG across 17 games with the Buffalo Bills, while TreVeyon Henderson posted 11.1 PPG in 17 appearances for the New England Patriots.

A 5.7-PPG gap gives James Cook the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.

Both profile as early-down workhorses. James Cook ran for 1621 yards and 12 touchdowns; TreVeyon Henderson posted 911 and 9. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.

Bye weeks matter for roster construction: James Cook sits Week 7 while TreVeyon Henderson is off Week 14. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.

Trade Value + Dynasty Outlook

If you can acquire James Cook at a discount because your league-mates undervalue running back production, do it. TreVeyon Henderson is a reasonable sell-high candidate if his recent games have spiked above his season average. Dynasty outlook: James Cook (age 26) is approaching the age where RB production historically drops. Sell-high window is open. TreVeyon Henderson (age 23) has not yet hit the RB cliff. High dynasty ceiling if volume holds.

Did You Know?

•James Cook outscored TreVeyon Henderson by a projected 97 total fantasy points over a full 17-game season.
•James Cook scored 14 total touchdowns in 2025 (0.8 per game), making him one of the more reliable scoring options at running back.
•TreVeyon Henderson caught 35 passes in 2025. Pass-catching backs average 2-3 more PPG in half-PPR than their non-receiving counterparts.

Detailed Stat Breakdown▾

StatCookHenderson

PPG (Half-PPR)16.811.1

Games Played1717

Total Fantasy Pts (est.)286189

Rushing Yards1,621911

Rush Yds/Game95.453.6

Rushing TDs129

Receptions3335

Receiving Yards291221

Targets4042

Total TDs1410

Age2623

Experience3 yrs-

Bye WeekWeek 7Week 14

Summary

James Cook outscored TreVeyon Henderson by 5.7 PPG in 2025 (16.8 to 11.1). That production gap is the baseline, but weekly context shifts the answer. DraftCall analyzes matchup difficulty, scoring trends, and health data to deliver a clear start or sit recommendation backed by real reasoning.

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Frequently Asked Questions

Should I start James Cook or TreVeyon Henderson in fantasy football?▾

Based on 2025 season averages, James Cook has the edge at 16.8 PPG compared to TreVeyon Henderson's 11.1 PPG. However, the best start depends on weekly matchup, recent form, and injury status. DraftCall's app provides real-time AI-powered verdicts that factor in all of these variables.

How many fantasy points did James Cook and TreVeyon Henderson average in 2025?▾

James Cook averaged 16.8 fantasy points per game (half-PPR) across 17 games in 2025. TreVeyon Henderson averaged 11.1 PPG over 17 games. That is a difference of 5.7 points per game.

When are James Cook and TreVeyon Henderson's bye weeks in 2026?▾

James Cook (BUF) has a bye in Week 7, and TreVeyon Henderson (NE) has a bye in Week 14. Plan your roster accordingly if you are carrying both players.

Is James Cook or TreVeyon Henderson a better fantasy running back in 2026?▾

James Cook outscored TreVeyon Henderson by 5.7 PPG in 2025, which gives him the edge heading into 2026. For a week-by-week verdict, DraftCall's AI analyzes matchup quality and recent trends in real time.