James Cook vs Nick Chubb: Who Should You Start?
The numbers tell a clear story here. James Cook put up 16.8 fantasy points per game for the Buffalo Bills in 2025, while Nick Chubb managed 5.5 across 15 games with the Houston Texans. A 11.3-point weekly edge is substantial at the running back position.
The per-game difference of 11.3 points favors James Cook, though savvy managers know that gap can shrink or widen depending on the weekly slate. Defensive matchup, recent scoring trends, and health status all shift the calculus from one running back to the other.
Both profile as early-down workhorses. James Cook ran for 1621 yards and 12 touchdowns; Nick Chubb posted 506 and 3. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
Bye weeks matter for roster construction: James Cook sits Week 7 while Nick Chubb is off Week 6. If you are deciding between the two as a season-long roster hold, the staggered byes actually work in your favor.
