James Conner vs James Cook: Who Should You Start?
Deciding between James Conner and James Cook is a common lineup dilemma for fantasy managers. The Arizona Cardinals running back put up 11.0 PPG in 2025 over 14 games; James Cook of the Buffalo Bills averaged 16.8 in 17. A 5.8-point margin that could shift on any given week.
The per-game difference of 5.8 points favors James Cook, though savvy managers know that gap can shrink or widen depending on the weekly slate. Defensive matchup, recent scoring trends, and health status all shift the calculus from one running back to the other.
Both profile as early-down workhorses. James Conner ran for 752 yards and 5 touchdowns; James Cook posted 1621 and 12. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
James Conner has his bye in Week 11, and James Cook rests in Week 7. Managers rostering both need waiver wire depth at running back for those two weeks, and that is exactly the kind of planning DraftCall's matchup engine surfaces automatically so you are not scrambling on a Sunday morning.
