Audric Estimé vs Joe Mixon: Who Should You Start?
There is a real production gap between these two running backs. Joe Mixon (Houston Texans) averaged 16.5 PPG over 15 games in 2025, outscoring Audric Estimé (New Orleans Saints, 8.4 PPG) by 8.1 points per week. That separation would need a significant matchup swing to overcome.
A 8.1-PPG gap gives Joe Mixon the edge on paper, but paper does not account for Thursday night matchups, weather games, or a star defender returning from injury. The real question is not who was better in 2025, but who is the better start this specific week.
Both profile as early-down workhorses. Audric Estimé ran for 198 yards and 1 touchdowns; Joe Mixon posted 1165 and 11. Goal-line share, red zone touches, and which team is favored are usually the tiebreaker when neither back offers passing-game volume.
One scheduling note: Audric Estimé is off Week 11 and Joe Mixon Week 14. If these two are on your roster, you will need a fill-in running back for both weeks. DraftCall flags bye conflicts so you can plan ahead rather than panic on waivers.
